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Relevence of Early Seizures for In-Hospital Mortality in Acute Cerebrovascular Disease
Neurol 47:1429-1435, Arboix,A.,et al, 1996
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Article Abstract
A total of 27 patients(2.5%)had epileptic seizures during the first 48 hours of stroke.Advanced age,confusional syndrome,hemorrhagic stroke,large lesions,involvement of parietal and temporal lobes,and occurrence of neurologic medical complications were significantly more frequent in seizure patients than in nonseizure patients.Overall in-hospial mortality rate was 33.3%in the seizure group and 14.2%in the nonseizure group(p=0. 02).The presence of early seizures was a significant predictive variable both in the model based on clinical variables(odds ratio[OR],5.5;95% confidence interval[CI],1.81 to 16.72)and in the model based on clinical neuroimaging variables(OR,6.1;95%CI,2.13 to 17.93).Seizures at the onset of a first-ever stroke is an independent prognostic factor for in-hospital mortality.Patients with the highest risk of developing epileptic seizures- aged persons with a large hemorrhagic infarction of a parietal lobe-may be candidates to be treated prophylactically against seizures for a few days.
 
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